Streptomycin Injectable

Generic Name: Streptomycin

Brand Names:

Availability: Available with Prescription

Drug Class: Aminoglycoside Antibiotics

Therapeutic action

  • Antibacterial (group of aminoglycosides)

Indications

  • Alternative to gentamicin in plague 
  • Brucellosis, in combination with doxycycline

Forms and strengths, route of administration

  • Powder for injection,vial containing 1 g of streptomycin base, to be dissolved in 3.2 ml of water for injection to obtain a 250 mg/ml solution, for IM injection.
  • DO NOT ADMINISTER BY IV INJECTION.

Dosage

Plague

  • Child: 15 mg/kg (max. 1 g) every 12 hours
  • Adult: 1 g every 12 hours

Brucellosis

  • Adult: 1 g once daily

Duration

  • Plague: 10 to 14 days
  • Brucellosis: 2 weeks

Contra-indications, adverse effects, precautions

  • Do not administer in patients with allergy to aminoglycosides.
  • Administer with caution to patients with history of renal, vestibular or auditory problems. 
  • Reduce the dose in patients with renal impairment.
  • May cause: irreversible ototoxicity (vestibular and auditory damage), nephrotoxicity, neuropathy, paraesthesia, neuromuscular blockade; rarely, allergic reactions.
  • Stop treatmentin the event of dizziness, tinnitus or hearing loss (ototoxicity). Drink sufficient liquid to limit the risk of renal toxicity.
  • Do not combine with another aminoglycoside.
  • Avoid or monitor combination with: furosemide, amphotericin B, vancomycin (enhanced renal and/or auditorytoxicity); neuromuscular blockers(increased neuromuscular blockage).
  • Pregnancy: CONTRA-INDICATED
  • Breast-feeding: no contra-indication

Storage

– Below 25 °C