Therapeutic action
Indications
- Eradication of Helicobacter pylori, in combination with omeprazole and amoxicillin
Forms and strengths
Dosage and duration
- Adult: 500 mg 2 times daily for 7 days
Contra-indications, adverse effects, precautions
- Do not administer to patients with allergy to clarithromycin or another macrolide.
- Maycause:
- headache, taste disturbances, insomnia, gastrointestinal disturbances, reversible hearing disorders;
- heart rhythm disorders (QT prolongation);
- hypersensitivity reactions sometimessevere (in this event, stop treatment immediately).
- Administer with caution and reduce dosage by half in patients with severe renal impairment. Avoid combination with drugs that prolong the QT interval: amiodarone, antimalarials, antipsychotics, efavirenz, fluconazole, fluoroquinolones, hydroxyzine, ondansetron, etc.
- Administer with caution and monitor combination with: oral antidiabetics, atorvastatin, carbamazepine, daclatasvir, digoxin, phenytoin, rifabutin(increased plasma concentrations of these drugs).
Pregnancy: avoid (safety not established)
Breast-feeding: no contra-indication
Remarks
Clarithromycin is also used for the treatment of non-tuberculous mycobacterial infections.
Storage
-Below 25 °C