Miconazole

Generic Name: Miconazole

Brand Names:

Availability: Available with Prescription

Drug Class: Azole antifungal

Therapeutic action

  • Antifungal

Indications

  • Mild oropharyngeal candidiasis

Forms and strengths

  • 2% oral gel (24 mg/ml) together with, depending on the manufacturer: 
    • a 2.5 ml measuring spoon with 1.25 ml and 2.5 ml graduation or
    • a 5 ml measuring spoon with 2.5 ml and 5 ml graduation

Dosage

  • Child from 6 months to 2 years: 1.25 ml 4 times daily 
  • Child over 2 years and adult: 2.5 ml 4 times daily

The oral gel should be kept in the mouth 2 to 3 minutes and then swallowed, or in young children, applied to the tongue and inside of each cheek.

Duration

  • 7 days; 14 days of treatment may be necessary.

Contra-indications, adverse effects, precautions

  • Do not administer:
    • to children under 6 months or patients with swallowing difficulties (risk of suffocation due to oral gel form);
    • in patients with hepatic impairment.
  • Do not combine with antivitamin K agents (risk of haemorrhage), glibenclamide (increased hypoglycaemic effect), phenytoin (increased plasma concentration of phenytoin).
  • May cause:nausea, taste disturbances.
  • Pregnancy: no contra-indication
  • Breast-feeding: no contra-indication

Remarks

  • Use the measuring spoon provided and check the graduation. 
  • Administer between meals (preferably after meals).
  • In patients with dentures, clean dentures with oral gel when removed.
  • In the event of moderate or severe oropharyngeal candidiasis, use oral fluconazole. 
  • Miconazole oral gel is not included in the WHO list of essential medicines.

Storage

– Below 25 °C