Antiretroviral, HIV-1 non nucleoside reverse transcriptase inhibitor
Indications
HIV-1 infection in neonates,in combination with other antiretrovirals
Forms and strengths
50 mg/5 ml oral suspension
Dosage
The daily dose is administered in 2 divided doses.
Child under one month:
Weight
50 mg/5 ml oral suspension (10 mg/ml)
2 to < 3 kg
1.5 ml x 2
3 to < 4 kg
2 ml x 2
4 to < 5 kg
3 ml x 2
Duration
Change to lopinavir/ritonavir granules(at 2 weeks of age) or dolutegravir dispersible tablet (at 4 weeks of age).
Contra-indications, adverse effects, precautions
May cause:
cutaneous reactions sometimes severe (Stevens-Johnson and Lyell syndromes), hepatic disorders possibly severe (fulminant hepatitis) and haematological disorders. In these cases, stop nevirapine immediately and permanently;
gastrointestinal disturbances (take with food to increase tolerance), headache, myalgia.
Avoid combination with rifampicin (decreases the efficacy of nevirapine).
Remarks
Nevirapine is also used for prophylactic treatment to reduce mother-to-child transmission and treatment of HIV-1 infection in children and adults, in combination with other antiretrovirals. Check national recommendations.
Storage
Below 25 °C
Once opened, oral suspension keeps for 2 months maximum.