Prevention of post-operative nausea and vomiting in children
Treatment of post-operative nausea and vomiting
Forms and strengths, route of administration
4 mg ampoule (2 mg/ml, 2 ml) for slow IV injection(3 to 5 minutes)
Dosage and duration
Prevention of post-operative nausea and vomiting
Child over 1 month: 0.1 mg/kg at the end of surgery(max. 4 mg per injection)
Treatment of nausea and vomiting
Child over 1 month:
No prophylactic dose of ondansetron received: 0.1 mg/kg every 8 hours if necessary
Prophylactic dose of ondansetron received and late postoperative vomiting (≥ 6 hours after surgery): 0.1 mg/kg every 6 hours if necessary Do not exceed 4mg per injection and 3 injections per 24hours.
Adult: 4 mg every 8 hours if necessary (max. 3 injections per 24 hours)
Contra-indications, adverse effects, precautions
Do not administer to children less than 1 month of age.
Administer with caution and monitor use in patients with congenital long QT syndrome, cardiac insufficiency and bradycardia.
Reduce the dose in patients with hepatic failure (max. 8 mg daily).
May cause: headache, sensation of flushing or warmth, hiccups, constipation, heart rhythm disorders, QT interval prolongation, extrapyramidal reactions, seizures, cutaneous allergic reactions (Lyell’s and Stevens-johnson syndromes).
Avoid or monitor combination with:
drugs that prolong the QT interval: amiodarone, bedaquilline, chloroquine, co-artemether, erythromycin, fluconazole, haloperidol, moxifloxacin, mefloquine, pentamidine, quinine, etc.;