Prevention of poliomyelitis, in combination with the inactivated poliomyelitis vaccine (IPV)
Composition, forms, route of administration
Live-attenuated virus vaccine, bivalent (poliovirus types 1 and 3)
Oral suspension in multidose vial, to be administered on the tongue, with dropper
Dosage and vaccination schedule
One dose = 2 drops (approximately 0.1 ml)
In endemic areas or areas at risk of poliovirus importation,
according to WHO recommendations Child: 4 doses approximately 4 weeks apart,at birth then at 6, 10 and 14 weeks of age
The 4th dose at 14 weeks is administered in combination with a dose of the inactivated
poliomyelitis vaccine (IPV).
Other areas
Child: 3 doses approximately 4 weeks apart, at 6, 10 and 14 weeks of age
The 3rd dose at 14 weeks is administered in combination with a dose of the inactivated poliomyelitis vaccine(IPV).
Contra-indications, adverse effects, precautions
Do not administer in the event of severe immuno depression (risk of paralyticpoliomyelitis): use the injectable vaccine IPV (asymptomatic HIV infection is not a contra-indication).
Vaccination should be postponed in the event of severe acute febrile illness(minor infections are not contra-indications).
May cause (exceptionally): paralyticpoliomyelitis.
In the event of vomiting or diarrhoea when the vaccine is administered, give the usual dose followed by an extra dose once gastrointestinal symptoms have improved.
Respect an interval of at least4 weeks between each dose.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication
Remarks
Protection against poliomyelitis lasts for life after 3 doses.
In children who start routine vaccination late (after the age of 3 months), the dose of IPV is administered together with the 1st dose of bOPV, followed by 2 doses of bOPV alone administered 4 weeks apart.
For the vaccination schedule,follow national recommendations.
Monovalent oral type 2 vaccines (mOPV and nOPV) are also available but are exclusively used for responding to epidemics.
Storage
For prolonged storage: freeze (– 20 °C).
After defrosting: between 2 °C and 8 °C for 6 months maximum.