Tenofovir Disoproxil Fumarate

Generic Name: Tenofovir Disoproxil Fumarate

Brand Names:

Availability: Available with Prescription

Drug Class: Nucleoside Reverse Transcriptase Inhibitors (NRTIs)

Therapeutic action

  • Antiretroviral, HIV nucleotide reversetranscriptase inhibitor

Indications

  • HIV infection with or without chronic hepatitis B coinfection, in combination with other antiretrovirals
  • Chronic hepatitis B without HIV coinfection, in monotherapy

Forms and strengths

  • 300 mg tablet, equivalent to 245 mg of tenofovirdisoproxil

Dosage

  • Child 35 kg and over and adult: 300 mg once daily

Duration

  • Depending on the efficacy and tolerance of tenofovir.

Contra-indications,adverse effects, precautions

  • Administer with caution and monitor use in patients with renal impairment, osteoporosis. In the event of deterioration of renal function, switch to another antiretroviral.
  • Avoid combination (or monitor renal function in the event of combination) with nephrotoxic drugs: aminoglycosides (e.g. gentamicin, streptomycin), amphotericin B, pentamidine, NSAIDs, etc.
  • May cause:
    • gastrointestinal disturbances (nausea, vomiting, diarrhoea, etc.), dizziness, fatigue,skin rash; 
    • renal impairment, bone loss (osteoporosis, fractures), pancreatitis.
  • Pregnancy: no contra-indication

Remarks

  • Tenofovir is also used for HIV pre-exposure and post-exposure prophylaxis, in combination with other antiretrovirals.
  • Also comes in fixed-dose combinations containing tenofovir and other antiretrovirals for the treatment of HIV infection.Preferably use these formulations when available.

Storage

– Below 25 °C